MARCHING FORWARD
IN NEW ORLEANS

Great food. Great jazz. And a history as colorful as the architecture.

For those in the hemophilia community, it's the big event of the year—the National Hemophilia Foundation's 62nd Annual Meeting. This year, New Orleans will play host on November 11-13, 2010, with the exciting theme, Marching Forward.

Get ready for 3 full days of learning programs, workshops, and many chances to meet and share ideas with other members of the community. In the spirit of the host city, a fun Mardi Gras closing party will cap it all off.

A Village that supports the community

Pfizer Hemophilia will be a platinum sponsor at this year's event, showing its commitment to community and innovation. Many of you have seen the exciting new Hemophilia Village Web site and all the news, resources, and real community stories it has to offer. At this year's Pfizer booth, you'll find Hemophilia Village brought to life. Stop by the Pfizer Hemophilia booth "The Village" and experience Hemophilia Village and the new advanced reconstitution technology. Pfizer is the only company that offers both recombinant hemophilia A and hemophilia B products, XYNTHA and BeneFix. You'll hear about Pfizer's innovation in convenience, the all-in-one reconstitution device—dual-chamber syringe with 3000 IU of XYNTHA. You'll be able to meet helpful representatives, as well as the hemophilia Ambassadors who will share real-life stories. You can look forward to other events and surprises as well, including great guest speakers. If you want inspiring news and innovation, make Hemophilia Village your top destination.

An Easy guide to the Big Easy

What will you find in New Orleans? World-class cuisine, music, shopping, and entertainment!

All that food: You'll be tempted at every turn by New Orleans' unique Cajun and Creole dishes. Some top restaurants include: Emeril's, Arnaud's, Commander's Palace, K-Paul's, and Bourbon House.

Among the city's favorite neighborhood hotspots: Mother's, Casamento's, Ralph's on the Park, and many more!

All that jazz: Whether it's a jazz brunch on Sunday, or a jazz band in a street parade, no trip to New Orleans would be complete without the jazz experience. Preservation Hall in the French Quarter is one of the most well known clubs in the city. Fritzel's, located on Bourbon Street, has the feel of a local pub complete with local musicians. The French Quarter Bar at the Ritz-Carlton on Canal Street is a great place for people watching—and movie star gawking. Snug Harbor is the best and oldest jazz hall on Frenchman Street. And this is just the beginning!

Learn more at HemophiliaVillage.com.

What Is XYNTHA?

Xyntha® Antihemophilic Factor (Recombinant), Plasma/Albumin-Free is indicated for the control and prevention of bleeding episodes in patients with hemophilia A (congenital factor VIII deficiency or classic hemophilia) and for surgical prophylaxis in patients with hemophilia A.

XYNTHA does not contain von Willebrand factor and, therefore, is not indicated in von Willebrand's disease.

Important Safety Information for XYNTHA

• Allergic reactions are possible with XYNTHA. Signs of an allergic reaction may include hives, rash with itching, chest tightness, difficulty breathing, faintness, or fast heartbeat. XYNTHA contains trace amounts of hamster protein. You may develop an allergic reaction to these proteins. Tell your doctor if you have had an allergic reaction to hamster protein.
• Call your doctor right away if bleeding is not controlled after using your factor VIII replacement therapy; this may be a sign of an inhibitor. Inhibitors have been observed in patients receiving factor VIII products, including XYNTHA.
• The most common adverse reaction in study 1 (safety and efficacy study) is headache (24% of subjects) and in study 2 (surgery study) is fever (41% of subjects). Other common side effects of XYNTHA include nausea, vomiting, diarrhea, or weakness.
• XYNTHA is an injectable medicine administered by intravenous (IV) infusion. Local irritation may occur when infusing XYNTHA after reconstitution in XYNTHA Solofuse.

Please see full Prescribing Information for XYNTHA.

What Is BeneFIX?

BeneFIX® Coagulation Factor IX (Recombinant) is an injectable medicine that is used to help control and prevent bleeding in people with hemophilia B. Hemophilia B is also called congenital factor IX deficiency or Christmas disease.

BeneFIX is NOT used to treat hemophilia A.

Important Safety Information for BeneFIX

• BeneFIX is contraindicated in patients who have manifested life-threatening, immediate hypersensitivity reactions, including anaphylaxis, to the product or its components, including hamster protein.
• Call your health care provider right away if your bleeding is not controlled after using BeneFIX.
• Allergic reactions may occur with BeneFIX. Call your health care provider or get emergency treatment right away if you have any of the following symptoms: wheezing, difficulty breathing, chest tightness, your lips and gums turning blue, fast heartbeat, facial swelling, faintness, rash or hives.
• Your body can make antibodies, called “inhibitors,” which may interfere with the effectiveness of BeneFIX.
• If you have risk factors for developing blood clots, such as a venous catheter through which BeneFIX is given by continuous infusion, BeneFIX may increase the risk of abnormal blood clots. The safety and efficacy of BeneFIX administration by continuous infusion have not been established.
• Some common side effects of BeneFIX are nausea, injection site reaction, injection site pain, headache, dizziness and rash.

Please see full Prescribing Information for BeneFIX.